What do u know about cytotec aka misoprosto

Chse 235         

Efosa Asemota

Drug report #2         

Cytotec/ Misoprosto

Therapeutic category

Mucosal Protective gent         

Use/ indicator

For the treatment and legal profession of NSAID-induced gastroduodenal ulcers. Also indicated for the treatment of duodenal ulcers caused by Peptic ulcer Disease (PUD).

Adverse reaction

The most frequent gastrointestinal adverse events were profligacy (10.7%), abdominal pain (7.3%), nausea (4.2%), flatulence (3.3%), and dyspepsia (3.2%). The relative incidence of diarrhea was 7.8% when the total daily dose was 400 & small;g. In patients receiving placebo, the incidence of diarrhea was 3.6%. The events were usually transient and piano to moderate in severity.

Contraindication/overdose

Possible clinical signs that may indicate an overdose may include: sedation, tremor, fever, convulsions, dyspnea, abdominal pain, diarrhea, palpitations, hypotension or bradycardia. Treatment should be symptomatic and supportive. Children: Safety and effectiveness in patients below the jump on of 18 have not been established. Known sensitivity to prostaglandins, prostaglandin analogues or excipients (microcrystalline and hydroxypropyl methylcellulose, sodium starch glycolate and hydrogenated castor oil). Contraindicated in pregnancy.

Initial dosage

The recommended adult oral exam dosage for the prevention and treatment of NSAID-induced gastroduodenal ulcer is 400 to 800 µg a day in divided doses. NSAIDs should be taken according to the schedule prescribed by the physician. When appropriate, misoprostol and NSAIDs atomic number 18 to be taken simultaneously. Misoprostol should be taken after food.

Reference:www.drugs.com, www.pharmclips.com, hypertext transfer protocol://www.rxmed.com,http://www.rxmed.com/b.main/b2.pharmaceutical/b2.prescribe.html

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